Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds
نویسندگان
چکیده
منابع مشابه
Copper-Mediated Amidation of Heterocyclic and Aromatic C−H Bonds
A copper-mediated aerobic coupling reaction enables direct amidation of heterocycles or aromatics having weakly acidic C-H bonds with a variety of nitrogen nucleophiles. These reactions provide efficient access to many biologically important skeletons, including ones with the potential to serve as inhibitors of HMTs.
متن کاملCu-Catalyzed Direct Amidation of Aromatic C–H Bonds: An Access to Arylamines
A Cu-catalyzed aromatic C-H amidation with phthalimide under oxygen as a terminal oxidant without using additional additives has been achieved. This reaction has the broad substrate scope and shows moderate to good yields in most cases. This method is complementary to the previously reported metal-catalyzed C-H amination systems.
متن کاملPractical copper(I)-catalysed amidation of aldehydes.
The direct synthesis of amides by insertion into the C-H bond of aldehydes is shown to be a practical procedure through application of cheap, readily available catalysts generated in situ from copper(i) halides and pyridine.
متن کامل6 Analysis of H – AHn and CH 3 – AHn bonds
Along the series of H–AHn bonds, with AHn = CH3, NH2, OH, and F, the bond dissociation energies show a steady increase as can be expected from the increasing difference in electronegativity along this series. However, in the same series for CH3– AHn the bond strength first decreases from CH3–CH3 to CH3–NH2 and only thereafter increases again along CH3–NH2, CH3–OH and CH3–F. To understand the or...
متن کامل7 Activation of H – AHn and CH 3 – AHn bonds
We have studied the palladium oxidative insertion reactions into a series of model bonds across the second period, that is, the H–AHn and CH3–AHn bonds, where AHn = CH3, NH2, OH, and F. We investigate what effect this series of increasingly polar bonds has on their intrinsic barriers upon activation by palladium. Our activation strain analyses show nicely how the observed trends are strongly in...
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2009
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol902079g